Javier J. Gonzalez-Rosa


My main research interests are in developing new approaches for integrating electrophysiological, structural and hemodynamic information, in the study of the spatio-temporal neural activation occurring during attentional, executive, and motor tasks. This approach may result in a more detailed functional brain evaluation from different perspectives which may enhance our knowledge about the time course of cognitive processes and voluntary actions both in healthy subjects and in different neurological and psychiatric diseases.

This includes the use of:

– Resting EEG and event-related potentials (ERP) analysis.
– Source EEG localization and reconstruction of the spatio-temporal pattern of ERP components.
– Multimodal integration of electrophysiological (EEG/ERP) and hemodynamic (fMRI) information obtained during simultaneous and separate EEG-fMRI recording sessions.
– Co-registration of EEG activity and trasncranial magnetic stimulation (TMS) and focal transcranial static magnetic field stimulation (tSMS).
– Co-registration and analysis of cortical EEG data and intracranial EEG (icEEG) information.

– To study the specific effects of Deep Brain Stimulation (DBS) on EEG activity and cognitive task performance.



Chieffo R, Straffi L, Inuggi A, Gonzalez-Rosa JJ, Spagnolo F, Coppi E, Nuara A, Houdayer E, Comi G, Leocani L. Motor cortical plasticity to training started in childhood: The example of piano players. PLoS One, 2016; 11(6):1-18.

Gonzalez-Rosa JJ. “Integración Multimodal: Métodos para la fusión de datos electromagnéticos (M/EEG) y hemodinámicos (fMRI)”. Chapter 2: “Técnicas y métodos de la Neurosciencia Cognitiva” (Authors: F. Maeztú, C. Ávila, A. Barrós-Loscertales, L. Carritiè, L. Fuentemilla, JJ. González-Rosa, E. Madrid, J. Marco-Pallarés). Mente y Cerebro: De la Psicología Experimental a la Neurociencia Cognitiva (En: MT Bajo, LJ Fuentes, J Lupiañez, y MR Rueda – Coords.). 1ª Ed., Alianza Universidad, 2016.

Nachev P, Lopez-Sosa F, Gonzalez-Rosa JJ, Galarza A, Avecillas J, Pineda-Pardo JA, Lopez-Ibor JJ, Reneses B, Barcia JA, Strange B. Dynamic risk control by human nucleus accumbens. Brain, 2015; 138(Pt 12):3496-502.

Gonzalez-Rosa JJ, Soto-Leon V, Real P, Carrasco-Lopez C, Foffani G, Strange BA, Oliviero A. Safety study of transcranial static magnetic field stimulation (tSMS) of the human cortex. Journal of Neuroscience, 2015; 35(24):9182-93.

Oliviero A, Carrasco-López MC, Campolo M, Perez-Borrego YA, Soto-León V, Gonzalez-Rosa JJ, Higuero AM, Strange BA, Abad-Rodriguez J, Foffani G. Safety study of transcranial static magnetic field stimulation (tSMS) of the human cortex. Brain Stimulation, 2015; 8(3):481-485.

Gonzalez-Rosa JJ, Natali F, Tettamanti A, Cursi M, Velikova S, Comi G, Gatti R, Leocani L. Action observation and motor imagery in performance of complex movements: evidence from EEG and kinematics analysis. Behavioural Brain Research, 2015; 281:290-300.

Houdayer E, Teggi R, Velikova S, Gonzalez-Rosa JJ, Bussi M, Comi G, Leocani L. Involvement of cortico-subcortical circuits in normoacousic chronic tinnitus: A source localization EEG study. Clinical Neurophysiology, 2015; 126(12):2356-65.

Galvao-Carmona A, González-Rosa JJ, Hidalgo-Muñoz AR, Páramo D, Benítez ML, Izquierdo G, Vázquez-Marrufo M. Disentangling the Attention Network Test: Behavioral, Even Related Potentials and neural source analyses. Frontiers in Human Neuroscience, 2014; 8(816):1-16.

Vázquez-Marrufo M, Galvao-Carmona A, González-Rosa JJ, Hidalgo-Muñoz AR, Borges M, Ruiz-Peña JL, Izquierdo G. Neural correlates of alerting and orienting impairment in multiple sclerosis patients. Plos One, 2013; 9(5):1-10.

González-Rosa JJ, Inuggi A, Cursi M, Blasi V, Falini A, Silva AM, Annovazzi P, Comi G, Leocani L. Response competition and response inhibition during different choice-discrimination tasks: evidence from source analysis during simultaneous EEG-fMRI. International Journal of Psychophysiology, 2013; 89(1):37-47.

Spagnolo F, Coppi E, Chieffo R, Straffi L, Fichera M, Nuara A, Gonzalez-Rosa JJ, Martinelli V, Comi G, Volontè MA, Leocani L. Interhemispheric balance in Parkinson’s disease: a transcranial magnetic stimulation study. Brain Stimulation, 2013; 6(6):892-897.

Vázquez-Marrufo M, González-Rosa JJ, Galvao-Carmona A,  Hidalgo-Muñoz A, Borges M, Ruiz-Peña JL, Izquierdo G. Retest reliability of individual P3 topography assessed by high density electroencephalography. Plos One, 2013; 8(5).

Chieffo R, Inuggi A, Straffi L, Coppi E, Gonzalez-Rosa JJ, Spagnolo F, Poggi A, Comi G, Comola M, Leocani L. Mapping early changes of cortical motor output after subcortical stroke: A transcranial magnetic stimulation study. Brain Stimulation, 2013: 6(3):322-9.

Riva N, Falini A, Inuggi A, Gonzalez-Rosa JJ, Fazio R, Amadio S, Cerri F, Del Carro U, Comola M, Comi G, Leocani L. Cortical activation to voluntary movement in Amyotrophic Lateral Sclerosis is related to corticospinal damage: electrophysiological evidence. Clinical Neurophysiology, 2012; 123(8):1586-92.

Inuggi A, Riva N, González-Rosa JJ, Amadio S, Amato N, Fazio R, Del Carro U, Comi G, Leocani L. Compensatory movement-related recruitment in amyotrophic lateral sclerosis patients with dominant upper motor neuron signs: An EEG source analysis study. Brain Research, 2011; 1425:37-46.

Cruz-Gomez J, Belenguer-Benavides A, Gonzalez-Rosa JJ, Simon-Gozalbo A, Forn C. A critical analysis of neuroimaging studies in relation to cognitive performance in multiple sclerosis patients. Revista de Neurología, 2011; 53(6):337-50.

González-Rosa JJ, Vázquez-Marrufo M, Vaquero E, Duque P, Borges M, Gómez CM, Izquierdo G. Clusters analysis of behavioural and event-related potentials during an attentional paradigm in remitting-relapsing and benign forms of Multiple Sclerosis. BMC Neurology, 2011, 11:64.

Cambiaghi M, Teneud L, Velikova S, Gonzalez-Rosa JJ, Cursi M, Comi G, Leocani L. Flash visual evoked potentials in mice can be modulated by transcranial direct current stimulation (tDCS). Neuroscience, 2011; 185:161-5.

Inuggi A, Filippi M, Chieffo R, Agosta F, Rocca MA, González-Rosa JJ, Cursi M, Comi G, Leocani L. Motor area localization using fMRI-constrained cortical current density reconstruction of movement-related cortical potentials, a comparison with fMRI and TMS mapping. Brain Research, 2010; 1308:68-78.

Cambiaghi M, Velikova S, Gonzalez-Rosa JJ, Cursi M, Comi G, Leocani L. Brain transcranial direct current stimulation modulates motor excitability in mice. European Journal of Neuroscience, 2010; 31(4):704-9.

Leocani L, Gonzalez-Rosa JJ, Comi G. Neurophysiological correlates of cognitive disturbances in multiple sclerosis. Neurological Science, 2010; 31(Suppl 2):s249-53.

Inuggi A, Amato N, Magnani G, González-Rosa JJ, Chieffo R, Comi G, Leocani L. Cortical control of unilateral simple movement in healthy aging. Neurobiology of Aging, 2011; 32(3):524-38.

Vázquez-Marrufo M, González-Rosa JJ, Vaquero-Casares E, Duque P, Borges M, Izquierdo G. Cognitive evoked potentials in remitting-relapsing and benign forms of multiple sclerosis. Revista de Neurología, 2009;48(9):453-8.

Gómez-Gonzalez C, Flores a, Digiacomo MR, Ledesma A, González-Rosa JJ. P3a and P3b components associated to the neurocognitive evaluation of invalidly cued targets. Neuroscience Letters, 2008.

Vázquez-Marrufo M, Gonzalez-Rosa JJ¸ Vaquero E, Duque P, Borges M, Gómez-Gonzalez C, Izquierdo G. Quantitative electroencephalography reveals different physiological profiles between benign and remitting-relapsing multiple sclerosis patients. BMC Neurology, 2008; 8:44.

Vaquero E, Gómez CM, Quintero EA, González-Rosa JJ, Márquez J. Differential prefrontal-like deficit in children after cerebellar astrocytoma and medulloblastoma tumor. Behavioral and Brain Functions, 2008; 4:18.

Vázquez-Marrufo M, Gonzalez-Rosa JJ¸ Vaquero E, Duque P, Borges M, Escera C, Izquierdo G, Gómez CM. Abnormal ERPs and high frequency bands power in multiple sclerosis. International Journal of Neuroscience, 2008; 118(1):27-38.

Gonzalez-Rosa JJ¸ Vázquez-Marrufo M, Vaquero E, Duque P, Borges M, Gómez CM, Izquierdo G. Differential cognitive impairment for diverse forms of multiple sclerosis. BMC Neuroscience, 2006; 7:39.

Gómez CM, Vaquero E, Vázquez M, González-Rosa JJ, Cardoso MJ. Alternate response preparation in a visuomotor serial task. Journal of Motor Behavior, 2005; 37(2):127-34.

Gomez CM, Fernandez A, Maestu F, Amo C, Gonzalez-Rosa JJ, Vaquero E, Ortiz T. Task-specific sensory and motorpreparatory activation revealed by contingent magnetic variation. Cognitive BrainResearch, 2004; 21(1):59-68.

Gómez CM, Vaquero E, Lopez-Mendoza D, Gonzalez-Rosa JJ, Vazquez-Marrufo M. Reduction of EEG power during expectancy periods in humans. Acta Neurobiologiae Experimentalis, 2004; 64(2):143-51.

Vaquero-Casares E, Cardoso-Moreno MJ, Vázquez-Marrufo M, González-Rosa JJ, Gómez-González CM. Gender-specific post-stimulus modulation in the alpha band during visual-spatial attention. Revista de Neurología, 2004; 39(2): 109-14.