Linda Zhang

Research Interest: Neuroimaging and neuropsychological correlates of healthy ageing and dementia, and early predictive biomarkers of Alzheimer’s disease.

ORCID: 0000-0003-2122-9771


“I am a postdoctoral researcher interested in the factors that determine whether an individual will maintain healthy cognitive function in old age or develop cognitive impairment and dementia.  I am currently working with the Vallecas Project cohort, a longitudinal cohort of healthy elderly people, to investigate the neuroimaging and neuropsychological differences between people who later develop cognitive impairment, and those who maintain healthy cognitive function.  I obtained my Bachelor’s degree at the University of Toronto (Psychology and Human Biology) and my PhD at the University of Hong Kong (Diagnostic Radiology) under the supervision of Dr. Henry Mak.”

Education

PhD (Diagnostic Radiology) at the University of Hong Kong, Hong Kong.

Hon. BSc (Human Biology, Psychology) at the University of Toronto, Canada.

Publications

  1.  Zhang L, Medina M, & Strange BA.  (in preparation) Construction and validation of the Vallecas Brain template: a cognitively normal elderly template from a Spanish cohort.
  2. Zhang L, Long CJ, Medina M, & Strange BA.  (in preparation) White matter loss in the healthy elderly brain indicative of impending cognitive decline.
  3. Zhang L, Duenas Ε, Long CJ, Navas S, Calero M, Medina M, & Strange BA.  (under review) Hippocampal volume of APOE ε4 carriers and noncarriers converge in the mid-8th decade.  JNeurosci
  4. B Strange, L Zhang, A Sierra-Marcos, E Alfayate, J Tohka, M Medina  (under review) Predicting the future development of mild cognitive impairment in the cognitively healthy elderly. 
  5. Zhang L, Cheung RT, Pa J, Yokoyama JS, Lee AKS, Chu LW, Rosen H, Weekes B, Miller B, & Mak HKF.  (editing for resubmission) Brain volumes differ between Caucasian and Chinese cognitively normal elderly controls.  
  6. Zhang L, Chang RCC, Chu LW, & Mak HKF (2012). Current neuroimaging techniques in Alzheimer’s disease and applications in animal models.  American Journal of Nuclear Medicine and Molecular Imaging, 2(3), 386-404.
  7. Mak HKF., Chan Q, Zhang Z, Petersen ET, Qiu D, Zhang L, Yau KKW, et al. (2012). Quantitative Assessment of Cerebral Hemodynamic Parameters by QUASAR Arterial Spin Labelling in Alzheimer’s Disease and Cognitively Normal Elderly Adults at 3-Tesla. Journal of Alzheimer’s disease: JAD, 31, 33-44.  
  8. Mak HKF, Zhang Z, Yau KKW, Zhang L, Chan Q, & Chu LW (2011).  Discriminating Alzheimer’s patients from cognitively normal older adults based on hippocampal volumes – voxel based morphometry with DARTEL and standard registration versus manual volumetry.  The Handbook of Alzheimer’s Disease, Imaging the Alzheimer’s Brain,Vol. 2. Mak HKF, Zhang Z, Yau KKW, Zhang L, Chan Q, & Chu LW (2011). Efficacy of voxel-based morphometry with DARTEL and standard registration as imaging biomarkers in Alzheimer’s disease patients and cognitively normal older adults at 3.0 Tesla MR imaging. Journal of Alzheimer’s disease: JAD, 23(4), 655-664.